Pht michaelis menton kinetic parameters have been reported to clinical pharmacology of antiepileptic drugs 181 be unchanged in aged patients compared with controls in the literature but a study in patients over the age range 21 to 78 found a 15 decrease in maximal rate of pht biotransformation vmax560 thus patients would tend to develop higher pht levels for the same doses than younger patients as steady state concentration varies inversely with vmax. The clinical pharmacology of traditional antiepileptic drugs despite the availability of newer agents a number of antiepileptic drugs have continued to be employed reasonably widely many years after their introduction to human therapeutics. Clinical pharmacology of antiepileptic drugs bazil carl w pedley timothy a author information the comprehensive epilepsy center the neurological institute of new york columbia university new york new york usa most of the material contained in this review was presented at the 54th annual meeting of the american academy of neurology and was included in a syllabus prepared for the . read clinical pharmacology of antiepileptic drugs uploaded by laura basuki clinical pharmacology of antiepileptic drugs 183 patients were on cbz vpa 5 27 than cbz alone 2 27 because vpa increases the cbz e cbz ratio the authors suggested that this effect was due to cbz e but vpa levels were high in the patients as well and may have contributed to the toxicity observed105 because of its . This article illustrates basic principles of clinical pharmacology presented in article 1 with specific examples from the treatment of seizure disorders the discussion includes protein binding the role of a major carbamazepine metabolite alterations in pharmacology of aeds in the elderly and aed withdrawal the last topic in particular is a good example of the interaction of